ABSTRACT
Patient with insulin dependant diabetes mellitus [IDDM] are liable to changes in the control of release of prolactin, lutenizing hormone [LH], and follicle stimulating hormone [FSH]. These changes may be due to altered hypothalamus-pituitary regulating mechanism. Inhibin is a peptide member of transforming growth factor family [TGF beta]. It is secreted by granulose and theca cells of the ovary. Its secretion from granulose cells is stimulated by FSH. The aim of the present work is to spotlight the exocrine and endocrine function in female adolescent with IDDM.20 adolescent female patients with IDDM [their ages ranging from I Ito 16 years] were subjected to history taking, clinical evaluation, serum estradio and FSH, LH and inhibin B level. Our patients showed no significant difference as regards serum estradiol, FSH, LH and serum inhibin B level when compared with the control group. Whereas serum level of some hormones [FSH, LH and inhibin B] were significantly increase in 10DM patients with regular menstrual cycles when compared with the 10DM patients with irregular menstrual cycles. No significant difference between the control group and IDDM patient with good, moderate or poor metabolic control were found as regards serum estradiol level, FSH, LH and serum inhibin B level. We conclude that our young diabetic females after mean disease duration of 9 years and various metabolic control, had serum inhibin B and gonadotropins comparable to those of normal subjects. Therefore they seem to have a regular ovarian function and in particular granulosa and theca cells despite of sustained hyperglycemia